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John Yu-Luen Lin
j8lin@ucsd.eduRESEARCH EXPERIENCE and INTERESTS
I
conducted my PhD study at University of Auckland under the supervision
of Professor Janusz Lipski and Associate Professor Gregory Funk. My PhD
studies focused on the functional characterizations of the neurons of
the basal ganglia system with mainly electrophysiological techniques. I
took up a short postdoctoral position under the supervision of Associate
Professor Gary Tong at the Burnham Institute at San Diego before joining
Professor Tsiens lab in 2006. My current research interests include
developing methods to manipulate and monitor the activities of neurons
and studying single-molecule photophysical properties of fluorescent
proteins. EDUCATION2000-2005 Doctor of Philosophy in Physiology, University of Auckland, Auckland, New Zealand 1996-1999 Bachelor of Technology (First class honours), University of Auckland, Auckland, New Zealand PUBLICATIONS
Lin
J.Y., Lin M.Z., Steinbach P. and Tsien R.Y. Characterization of
engineered channelrhodopsin variants with improved properties and
kinetics. (2009) Biophysical Journal. (In Press)
Sheng G.,
Chang G.Q.,
Lin J.Y.,
Yu Z.X.,
Fang Z.H.,
Rong J.,
Lipton S.A.,
Li S.H.,
Tong G.,
Leibowitz S.F.,
Li X.J. (2006)
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding
behavior. Nature Medicine
12,
526-533
Lin
J.Y., Chung K.K.H., de Castro D., Funk G.D. & Lipski J. (2004) Effects
of muscarinic acetylcholine receptor activation on membrane currents and
intracellular messengers in medium spiny neurones of the rat striatum.
European Journal of Neuroscience 20, 1219-1230.
Teo
M.-Y., van Wyk M., Lin J., and Lipski J. (2004) Differential effects of
nicotine on the activity of Substantia Nigra and Ventral Tegmental Area
dopaminergic neurons in vitro. Acta Neurobiologica Experimentalis 64,
119-130.
Lin
J.Y., van Wyk M., Bowala T.K., Teo M.Y. & Lipski J. (2003) Dendritic
projections and dye-coupling in dopaminergic neurons of the substantia
nigra examined in horizontal brain slices from young rats. Journal of
Neurophysiology 90, 2531-2535.
Lin
J.Y., Dubey R., Funk G.D. & Lipski J. (2003) Receptor subtype-specific
modulation by dopamine of glutamatergic responses in striatal medium
spiny neurons. Brain Research 959, 251-262.
Lipski
J. Lin J.Y., Teo M.Y. & can Wyk M. (2002) The network vs. pacemaker
theory of the activity of RVL presympathetic neurons a comparison with
another putative pacemaker system. Autonomic Neuroscience: Basic and
Clinical 98, 85-89.
Lin J.Y.
& Lipski J. (2001) Dopaminergic substantia nigra neurons express
functional NMDA receptors in postnatal rats. Journal of Neurophysiology
85, 1336-1339.
During
M.J., Symes C.W., Lawlor P.A., Lin J., Dunning J., Fitzsimons H.L.,
Poulsen D., Leone P., Xu R., Dicker B.L., Lipski J. & Young D. (2000) An
oral vaccine against NMDAR1 with efficacy and experimental stroke and
epilepsy. Science 287, 1453-1460. GRANTS, SCHOLARSHIP & PRIZES
Grants 2004 University of Auckland Graduate Research Fund University of Auckland
2004 IBRO Asia-Pacific
Region Travel grant - IBRO 2002 University of Auckland Research Fund University of Auckland
Fellowship 2005-2008 FRST post-doctoral fellowship Foundation of Research, Science and Technology in New Zealand
Scholarships 2004 Surdan Foundation
Scholarship - MBL Neurobiology course 2004 Frank Morrell Endowed Memorial Scholarship - MBL Neurobiology course 2003-2004 University of Auckland Doctoral Scholarship University of Auckland 2000-2003 Bright Future Top Achiever Doctoral Scholarship Foundation for Research Science & Technology, NZ 2000 University of Auckland Faculty of Science Postgraduate Student Award University of Auckland 1999 University of Auckland Masters / Honours Scholarship University of Auckland
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